A hybrid photonic-plasmonic antenna nanocavity-based biosensor associated with a single molecule was proposed [70] by Liang et al. More specifically, the immobilization of a xeroderma pigmentosum (XP) gene-encoded protein XPA in the presence of a DNA sequence was reported on a self-assembled monolayer of alkane thiol, named 11-mercaptoundecanoic acid (11-MUA), tethered on a gold surface. This evidence concerns the gene XPA and xeroderma pigmentosum.