Although in skin melanoma, the amount of cDC1 cells is low, e.g., in tg(Grm1)EPv mice, the amount of cDC1 positive cells in skin melanomas was less than 1% of the CD45+ cells, compared to more than 2% cDC2 and about 8% Langerhans cells [215], cDC1 still had important anti-tumoral effects. This evidence concerns the gene GRM1 and cutaneous melanoma.