ARPC1B knockdown significantly attenuates PC3 cells proliferation, as shown in Figure 5A, and reduced the wound healing ability of these high metastatic cells, as shown in Figure 5B. Furthermore, silencing ARPC1B significantly impaired PC3 and DU145 prostate cancer cells migration and invasion ability, as shown in Figure 6A. The gene discussed is ARPC1B; the disease is Familial prostate cancer.