lncRNA-HOTTIP is upregulated in mitomycin-resistant CRC cells and can confer mitomycin resistance following encapsulation into exosomes; mechanistically, lncRNA-HOTTIP increases the levels of karyopherin subunit alpha 3 (KPNA3) in sensitive cells, by binding to miR-214 [85]. The gene discussed is HOTTIP; the disease is colorectal carcinoma.