HEPH and malignant colon neoplasm: Finally, Zhang et al. associated methotrexate resistance with exosomal CAF-derived miR-24-3p; miR-24-3p overexpression was reported to enhance resistance of colon cancer cells to MTX by down-regulating the caudal-related homeobox 2/hephaestin (CDX2/HEPH) axis [81].