Szczepanski et al. found that TEX isolated from AML patients, containing membrane-associated transforming growth factor-β1 (TGF-β1), MICA/MICB and myeloid blast markers (CD34, CD33, and CD117), decreased NK cell cytotoxicity and down-regulated the expression of NKG2D in normal NK cells [48,100]. This evidence concerns the gene TGFB1 and acute myeloid leukemia.