In contrast, Plebanek et al. have shown that the “non-metastatic” TEX stimulated an innate immune response through the expansion of Ly6Clow patrolling monocytes in the bone marrow, which then cause cancer cell clearance at the pre-metastatic niche via the recruitment of NK cells and TRAIL-dependent killing of melanoma cells by macrophages [180]. Here, TNFSF10 is linked to melanoma.