MMP23B and non-small cell lung carcinoma: Wu et al. [48] showed, with endothelial monolayers and mouse models, that small EVs enriched in lnc-MMP2-2 (long noncoding-matrix metalloproteinase2-2) can weaken the BBB by destroying tight junctions, thus promoting the metastasis of non-small-cell lung cancer; moreover, he concluded that lnc-MMP2-2 knockdown significantly decreases the in vivo brain metastasis of NSCLC.