AKT1 and Familial prostate cancer: All available data show that Akt is hyperactive in cancer cells, and many types of human cancer are associated with the upregulation of Akt [158], for example, gastric carcinoma, glioblastomas, gliosarcomas, head and neck squamous cell carcinoma, pancreatic, ovarian, breast, and prostate cancers [159,160,161].