In HCC patients’ ALDOB (glycolytic metabolizing enzyme), APOC3 (Apolipoprotein C gene), APOH (Apolipoprotein H), CYP2E1 and CYP3A4 (members of cytochrome P450 enzyme system), Gc globulin, HRG (Histidine rich glycoprotein), Linc01554 (long intergenic non-protein coding RNA 1554), and pyruvate dehydrogenase kinase 4 (PDK4) being expressed significantly lower compared to normal tissues indicates poor prognosis while high expression of thioredoxin (TXN) was correlated with carcinogenic effect. The gene discussed is CYP3A4; the disease is hepatocellular carcinoma.