In HCC patients’ ALDOB (glycolytic metabolizing enzyme), APOC3 (Apolipoprotein C gene), APOH (Apolipoprotein H), CYP2E1 and CYP3A4 (members of cytochrome P450 enzyme system), Gc globulin, HRG (Histidine rich glycoprotein), Linc01554 (long intergenic non-protein coding RNA 1554), and pyruvate dehydrogenase kinase 4 (PDK4) being expressed significantly lower compared to normal tissues indicates poor prognosis while high expression of thioredoxin (TXN) was correlated with carcinogenic effect. This evidence concerns the gene HRG and hepatocellular carcinoma.