After 7 days of induced colitis, upregulation of the expression of 22 genes (Ccl2, Ccl3, Ccl4, Ccl5, Ccl6, Ccl7, Ccl12, Ccl17, Cxcl1, Cxcl2, Cxcl6, Cxcl9, Cxcl11, Ccr1, Ccr2, Ccr3, Ccr5, Ccr8, Cxcr2, Csf3, Osm, and Spp1) was observed in the CβG− group compared to the HβG- control group. The gene discussed is SPP1; the disease is colitis.