Our study, to the best of our knowledge, is the first comprehensive report on the effect of colitis itself and the modulatory effect of oat beta-glucans of various molar mass consumption on the expression of chemokines and their receptors as well as other colon inflammation-related proteins such as OSM, CSF3, and OPN (coded by the Spp1 gene) in an experimental model of TNBS-induced IBD. This evidence concerns the gene SPP1 and colitis.