In many cases, TIA1-mediated inflammatory responses have pathophysiological consequences associated with disorders such as arthritis, phagocytosis/autophagy, atherosclerosis, angiogenesis, neuroinflammation, obesity, myopathy, tauopathy and cancer [32,40,92,93,97,128,129,130,131] (Figure 5 and Figure 6). This evidence concerns the gene TIA1 and arthritic joint disease.