There are several well-documented links between autophagy responses, SGs and human pathologies, such as tau-associated pathology [86], Parkinson’s disease and other neurodegenerative disorders (e.g., Alzheimer’s disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), tauopathies and frontotemporal lobar dementia (FTLD)) [86,116]. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.