TIA1 and proximal spinal muscular atrophy: In a recent study analyzing the effect of TIA1 KO in a murine model of mild SMA [109], the authors verified that although TIA1 is involved in Smn2 splicing, it is not an essential regulator of this event, as was previously believed to be the case in humans [93,163], and its deletion does not significantly affect exon-7 skipping [109].