AQP1 overexpression has been shown to increase cellular migration and enhance extravasation from blood vessels and the invasion of tissues [399], while the loss of AQP1 functionality reduces angiogenesis, tissue invasion, and metastasis in many cancer types, including glioma [411], melanoma [444], mammary gland [445], colon [446], and lung cancers [398,420,447]. Here, AQP1 is linked to melanoma.