Hyperglycemia enhanced IL-1RA secretion after all stimulations; however, the effect was only statistically significant 6 h after stimulation with Hb-Hp2-2 complexes (1 μg/mL: 2.24 times, p-value < 0.05; 10 μg/mL: 2.03 times, p-value < 0.01) and 24 h after stimulation with 10 μg/mL Hb-Hp1-1 complexes (2.04 times, p-value < 0.05). Here, GSTM1 is linked to Hyperglycemia.