However, hyperglycemia significantly enhanced TNFα release 6 h after stimulation with Hb-Hp2-2 complexes (1 μg/mL: 1.65 times, p-value < 0.01; 10 μg/mL: 1.61 times, p-value < 0.01) (Figure 3B). The gene discussed is GSTM1; the disease is Hyperglycemia.