The secretion of the anti-inflammatory cytokine IL-1RA was enhanced 6 h after stimulation with Hb-Hp1-1 complexes in both normo- and hyperglycemia; however, the effect was only statistically significant in NG (1 μg/mL: 1.8 times, p-value < 0.05; 10 μg/mL: 1.66 times, p-value < 0.05, Figure 3F). Here, GSTM1 is linked to Hyperglycemia.