Full-length cadherin-17 [102], CD147 [103], cellular prion protein [104], GCLM (glutamate-cysteine ligase modifier subunit), KEL (Kell metallo-endopeptidase), APOF (apolipoprotein F), CFB (complement factor B), PDE5A (phosphodiesterase 5A), and ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) [105] were found to be secreted by specific CRC-derived sEVs and therefore may potentially be biomarkers for diagnosing CRC in the future. The gene discussed is PDE5A; the disease is colorectal carcinoma.