On the other hand, mutations in desmoglein and SAP97 have been described in BrS patients [380,381], but their influence on SCN5A/Nav1.5 remains to be elucidated, while calmodulin, CamKII, and GPD1L modulation of SCN5A/Nav1.5 is well-established [157,163,382,383], but to date, no mutation in these genes have been reported in the context of Brugada syndrome. This evidence concerns the gene SCN5A and Brugada syndrome.