Furthermore, targeting NOX2 by histamine treatment produced less immunosuppressive intratumoral myeloid derived suppressor cells (MDSCs) and reduced the growth of EL-4 lymphoma while improved the antitumor efficacy of immune checkpoint blockade with antibodies against the programmed cell death receptor 1 (PD-1) and the PD-1 ligand (PD-L1) in EL-4-bearing mice [44]. The gene discussed is CYBB; the disease is lymphoma.