Although in colon cancer the activation of H4R induced cell proliferation and VEGF expression, in other cancer subtypes including, melanoma, cholangiocarcinoma, oral squamous cell carcinoma, and breast, esophageal and lung cancers, histamine via H4R reduced proliferation, epithelial to mesenchymal transition, or tumor spread [11,18,38,39,40,41,42]. Here, HRH4 is linked to cholangiocarcinoma.