CASP3 and neoplasm: Although our data showed an enhancement of the expression of markers of tumor progression as a consequence of the ectopic expression of IKKα in both localizations, this is even more outstanding in C57-N-IKKα cells, which in addition to the increased levels of MMP9, Akt, Bcl2 and the decreased detection of cleaved-Caspase 3, they induce the expression of c-Myc, that in turn may contribute to the EMT process [43].