Additionally, the overexpression of IKKα in the nucleus of C57 cells causes an acquisition of a marked fibroblastoid phenotype and induces the transcription of Snail1 (which has a pivotal role in the EMT process [56]) and Vimentin, and represses the expression of K5; therefore, the switch in the expression of the epithelial marker K5 toward that of Vimentin correlates with the morphological change detected in the shape of C57-N-IKKα cells [56]; the induction of Snail1 by nuclear IKKα was also observed in NSCLC cells [44]. This evidence concerns the gene VIM and non-small cell lung carcinoma.