Recent results from our group and others [5,15,16,17] have underscored the relevance of studying the nuclear or cytoplasmic localization of IKKα for the understanding of the mechanisms of the protumoral role of IKKα in NMSC and other types of cancer [15]; therefore, here, we have generated variants of the PDVC57 skin carcinoma cells that express exogenous IKKα in the nucleus or in the cytoplasm. This evidence concerns the gene CHUK and skin carcinoma.