Several regulators of angiogenesis promote vascularization during GBM progression, including VEGF, basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), TGF-β, MMPs, and angiopoietins (Angs) [111]. The gene discussed is VEGFA; the disease is glioblastoma.