Our observations of a renoprotective effect of Nrf2 comply with previous studies that showed aggravation of diabetic nephropathy [27] and autoimmune nephritis [28] in mice lacking Nrf2, protection from ischemia-reperfusion injury in mice with tubular hyperactivation of Nrf2 [29], and increased glomerular filtration rates in patients with chronic kidney disease that were treated with an Nrf2 activator [30]. Here, NFE2L2 is linked to chronic kidney disease.