XIAP and glioblastoma: Moreover, other reports demonstrated efficacy of QCT in glioblastoma treatment occurring through inhibition of the PI3K/AKT pathway [13], reduction of X-linked inhibitor of apoptosis protein (XIAP) expression [17], G2-dependent cell cycle arrest [8], modulation of intracellular pH (pHi), as well as regulation of matrix metalloproteinases (MMPs) -2/-9, and vascular endothelial growth factor (VEGF) expression [7,18].