Genome-wide methylation analysis of adipose tissues after six months of endurance training demonstrated changes in the DNA methylation of 63 genes involved in obesity and diabetes, including KCNQ1 (potassium voltage-gated channel subfamily Q member 1), HHEX (haematopoietically expressed homeobox), IGF2BP2 (insulin-like growth factor 2 mRNA binding protein 2), JAZF1 (JAZF zinc finger 1), and TCF7L2 (transcription factor 7 like 2) [88]. This evidence concerns the gene IGF2BP2 and obesity due to melanocortin 4 receptor deficiency.