MMP-2-null mice were protected from cardiac rupture following MI, as were control mice treated with the MMP-2 (and MMP-9) inhibitor TISAM [(2R)-2-[5-[4-[ethyl-methylamino]phenyl]thiophene-2-sulfonylamino]-3-methylbutyric acid], despite no differences in infarct size [42]. Here, MMP2 is linked to myocardial infarction.