EGFR and glioblastoma: With regard to the Cancer Genome Atlas Consortium (TCGA), molecular classification of nearly 600 GBM tumors, mutated genes TP53, epidermal growth factor receptor (EGFR), IDH1, and phosphatase and tensin homologue (PTEN) [41], as well as the three core pathways, namely p53, RB, and receptor tyrosine kinase (RTK)/Ras/phosphoinositide 3-kinase (PI3K) signaling, were reported [42].