Transcription factors ZEB1 (Zinc finger E-box binding homeobox 1) and ZEB2 (Zinc finger E-box binding homeobox 2) specifically bind to multiple enhancer boxes (E-boxes) located within the transcription regulatory regions of the E-cadherin gene, and their interaction inhibits E-cadherin expression and, in this way, ZEB1 and ZEB2 genes serve as key drivers of EMT in multiple human cancers [16,17]. The gene discussed is ZEB2; the disease is cancer.