Data on the significant hypermethylation of the MIR203A gene in primary ovarian metastatic tumors and almost complete absence of MIR203A methylation in tumors of OvCa patients without metastases, which were in full agreement with the most significant decrease in the expression level of this gene in metastatic primary tumors, indicated the role of this miRNA in the initial stage of metastasis. This evidence concerns the gene MIR203A and metastatic neoplasm.