In more aggressive melanomas, a set of 4 upregulated genes (IGF2BP1, PTMA, MYC, MITF) was identified and a prognostic signature of 13 genes for metastatic CM was reported (CDKN2A, CDKN2B, ZBTB16/PLZF, CDKN1A, TYR, ARNT2, MDM2, GPR143, RAB38, ANGPT2, MGAT5, POU4F1, SIX1) [75,76]. This evidence concerns the gene ZBTB16 and melanoma.