Interestingly, two other groups [63,120] were unable to confirm this observation when screening the populations of the UK and Ireland, though one of them, Hatunic et al. [63] did find that the Leu262Val PARL genetic variation is associated with an earlier onset of diabetes and may be a marker of increased susceptibility to nephropathy and cardiovascular complications in patients with diabetes. Here, PARL is linked to diabetes mellitus.