Gabexate has a short half-life of approximately 1 min, necessitating continuous infusion, and may be more effective in sepsis-associated DIC than in aortic aneurysm-associated DIC because it also inhibits the release of tumor necrosis factor-α (TNF-α) [72] and inhibits cytokine release from macrophages [73]. Here, TNF is linked to aortic aneurysm.