Based on TCGA PanCancer Atlas data (NIH, Bethesda, MD, USA) comprising 594 colorectal adenocarcinoma samples, PTK7 and ADAMTS10 genes showed the highest overall somatic alteration frequency of around 4%, suggesting these two genes to be the most likely candidates for the development of CRC in the studied family. The gene discussed is PTK7; the disease is colorectal carcinoma.