It is important to note that, besides being involved in the production of tumor-promoting cytokines, S1PR1 signaling was also shown to have anti-inflammatory properties that include the suppression of anti-tumor mediators such as IL-12 and nitric oxide (NO) production by macrophages [54,153,154], as well as the suppression of endothelial cell activation [155]. Here, S1PR1 is linked to neoplasm.