To be able to discuss this question, we explored Pubmed using the following search terms: sphingosine-1-phosphate, S1P, S1PR1/2/3/4/5, sphingosine kinase, SPHK1/2, S1P Lyase, SGPL1, S1P phosphatase, SGPP1/2, PLPP3 in combination with cancer and immunity, immune, or inflammation in all possible permutations. This evidence concerns the gene SPHK1 and cancer.