SPHK2 and infectious otitis media: Interestingly, also SPHK2 may be involved in CAC, since the SPHK2 inhibitor ABC294640 prevented the development of AOM/DSS tumors and altered the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway not only in epithelial but also infiltrating inflammatory cells [124].