EIF5A and cancer: The overexpression of both eIF5A isoforms has been observed in several tumors and triggers cell migration, invasion, and cancer metastasis (see review [51] for details), but EIF5A2 is considered a potential oncogene and diagnostic or prognostic marker [61,62] because it is associated with poor survival, advanced disease stage, poor response to chemotherapeutic drugs, and metastasis.