In amphibian kidney cells, dexamethasone was shown to down-regulate MR [35] and in LPS-induced uveitis model, we showed that MR down-regulation in iris/ciliary body coincided with high corticosterone levels together with an increase expression of 11β-hsd1 [32] suggesting that both endogenous and exogenous corticoids could also regulate MR expression. Here, NR3C2 is linked to uveitis.