Importantly, these previously identified obesity GWAS SNPs that other investigators associated with LYPLAL1 (Supplementary Figure S9) exhibit moderate LD (r2 = 0.35 to 0.68, EUR) with Tier-1 SNPs in the promoter region of RP11-392O17.1. Here, LYPLAL1 is linked to obesity due to melanocortin 4 receptor deficiency.