In a direct manner, platelet receptors like αIIbβ3 and αVIβ1 can bind to tumor αVβ3 and ADAM9 respectively, as well as binding with P-selectins through PSGL-1 interaction, platelet toll-like receptor 4 and facilitating CLEC2-podoplanin interactions [10,11,12,13,14]. This evidence concerns the gene TLR4 and neoplasm.