Counterintuitively, a study in 2020 found increased transcriptional levels of the antioxidant enzymes peroxiredoxin 3 (PRDX3), CAT, and GPX1 in RPE cells, with decreased complement factor H (CFH) activity, which is commonly seen in the RPE cells of AMD patients [162]. The gene discussed is PRDX3; the disease is age-related macular degeneration.