BCL2L1 and neoplasm: Apoptotic process can be regulated by p53, a tumor suppressor that is able to modulate key control points in both intrinsic and extrinsic pathways [14]; it transcriptionally upregulates apoptosis-related proteins (i.e., Puma, Noxa, Bid, and Bax) expression and physically interacts with and neutralizes the anti-apoptotic activity of Bcl-2 and Bcl-xL; moreover, it can transactivate the death receptor genes and/or induce those (e.g., PTEN) that inhibit antiapoptotic pathway such as the survival PI3K/AKT signaling [14].