Genomic characterizations of ACC that identified a correlation between tumor onset and several genetic mutations—including TP53, CTNNB1, IGF2, PRKAR1A, RPL22, TERF2, CCNE1, and NF1 genes [264,265]—revealed high heterogeneity and histotype-specific genomic profiles [266]. This evidence concerns the gene IGF2 and adrenal cortex carcinoma.