In the case of the ADP-ribosylation factor (ARF)/ARF-like protein (ARL) family, it was observed that a high expression of ARL4D, ARL1, ARF1, and SAR1B in endometrial cancer is associated with better prognosis, while a high expression of ARL4C, ARL2, ARL10, ARL16, and ARL14 promotes worse survival. The gene discussed is ARL16; the disease is endometrial cancer.