Our earlier studies showed that conjugates of NSAIDs, namely, aspirin, indomethacin (IND), or diclofenac (DCL) with novel synthetic oxime derivatives of OA (OAO) enhanced their modulating effect on Nrf2-ARE and NF-κB signaling pathways in hepatoma cancer cells (HCC), resulting in increased apoptosis rate and reduced cell proliferation. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.