ENG modulates transforming growth factor-β (TGFβ) superfamily signaling and regulates endothelial quiescence and angiogenesis, and its mutation results in hereditary hemorrhagic telangiectasia type 1 (HHT1), an autosomal dominant vascular disorder [7,8]. This evidence concerns the gene TGFB1 and telangiectasia, hereditary hemorrhagic, type 1.