GPR37 and Parkinson disease: In two cell culture models of Parkinson’s disease associated with overexpression of Parkin-associated endothelin receptor-like receptor (Pael-R) and α-synuclein, IPA significantly reduced ROS-associated cell death [163] Additionally, patients with Huntington’s disease have lower plasma concentration of IPA, which might be associated with system-wide decreased ability to protect against ROS formation [87].