The prepared PLGA_OXA_Ab and PLGA_IO-OA_OXA_Ab in this study demonstrated the proper interaction of the nanoparticles with the CD133 cell surface antigen, which can confirm the delivery of the multicomponent system and can be used as a drug delivery of OXA, as the metabolic assay showed the elimination of the cancer cells. This evidence concerns the gene PROM1 and cancer.