PROM1 and colorectal cancer: Surface modification of PLGA nanoparticles was achieved by conjugation with an anti-CD133 monoclonal Ab (conjugated to Alexa Fluor 488), which can enable it to target the PLGA nanoparticles with its cargo (e.g., OXA) and, thus, enhance the cargo efficacy, improving distribution and concentration at the site of action in the colorectal cancer cells [39,43].