While the mechanism by which SARS-CoV-2 infection downregulates ACE2 expression remains to be fully clarified, one of the proposed mechanisms for SARS-CoV-2 is through TNF-α; the infection induces the shedding of ACE2 via the upregulation of TNF-α-converting-enzyme (TACE) [15,16]. The gene discussed is ADAM17; the disease is infection.