To investigate the functional role of TRIM37 in pancreatic cancer, the mouse pancreatic cancer cell line, Pan18-GFP-Luc (Pan18), and human pancreatic cancer cell lines, BxPC-3 and PANC-1, were infected with lentivirus bearing shTRIM37 plasmid to knockdown the expression of TRIM37. The gene discussed is TRIM37; the disease is familial pancreatic carcinoma.