These pathological events are critically associated with organ failure [34], hence the need to find effective therapies to treat the excessive and uncontrolled systemic inflammatory response [35,36].We provide evidence that the absence of Gal3 reduces the toxicity in a model of LPS-induced endotoxemia as evidenced by a significant reduction in the mortality rate and more preserved tissue integrity. This evidence concerns the gene LGALS3 and serum lipopolysaccharide activity.