To demonstrate conclusively that Gal3 plays a deleterious role in SIRS, and considering that appearance of MODS is critical for life expectancy of patients, we took advantage of (i) optic and electronic microscopy techniques to analyze those organs severely compromised during SIRS including liver, spleen, and lung and (ii) analysis of the death rate. The gene discussed is LGALS3; the disease is systemic inflammatory response syndrome.