In fact, LPS-induced endotoxemia induces arterial hypotension, lactic acidosis, tachycardia, and specific temporal elevations of circulating levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and high mobility group box (HMGB)-1 [2], which are important features of sepsis and septic shock. The gene discussed is TNF; the disease is lactic acidosis.