A better understanding of ALB binding sites, with the innovative aim of genetic manipulation, may be useful in different clinical contexts: in regulating the clearance of fatty acids, as previously mentioned, through mutation at position 218 or for the presence of additional SH group(s); high-affinity mutants may have an application in the emergency serological accumulation of endogenous substances, such as drug overdose; in dialysis, which is an extracorporeal treatment for patients with end stage renal disease consisting in the removing of water-soluble and ALB-bound toxins [57]. Here, ALB is linked to chronic kidney disease.