Although the PSMA-specific binding affinity [18F]F-YC-88 is one order of magnitude lower than those of its parent compounds, [18F]F-DCFBzL and [18F]F-DCFPyL, a head-to-head comparison of [18F]F-DCFPyL with [18F]F-YC-88 demonstrated reduced accumulation of [18F]F-YC-88 in major non-target tissues including the liver, kidneys, and spleen, which resulted in a high tumor/kidney ratio (4:1), likely due to the higher hydrophilicity (logP = −3.91. The gene discussed is FOLH1; the disease is neoplasm.