In conclusion, considering that soluble MerTK receptor promotes endothelial cell recruitment in breast cancer [17] and that choroidal neovascularization is reduced in ADAM9 k/o mice, it may be hypothesized that increased levels of sMer induced by HG, besides impairing phagocytosis, may also favor ocular neovascularization. The gene discussed is ADAM9; the disease is breast carcinoma.