Since IL-1α, IL-6, and IL-8 are known as skin inflammation molecular markers [33,34,35], and these markers have been found to be upregulated by paclitaxel in some cancer cell lines [7,11,36], we analyzed whether paclitaxel could mediate an inflammatory response in the 3D epidermis model through the induction of such cytokines. Here, IL6 is linked to cancer.