The CaN/NFAT pathway is activated in multiple cancers, including breast cancer [153], lung cancer [154], prostate cancer [155], ovarian cancer [118], pancreatic cancer [115], liver cancer [156], colorectal cancer [39], glioblastoma [138,157], melanoma [158], leukemia [159,160], and lymphoma [161,162]. The gene discussed is NUP214; the disease is breast carcinoma.