GSK3B and Cognitive impairment: Using a multitude of approaches, it was concluded that low levels of testosterone—a physiological occurrence in neonatal male pups—could be a culprit for their vulnerability to sevoflurane-induced cognitive impairment [71] as administration of exogenous testosterone to male neonatal mice reduced tau phosphorylation and prevented cognitive impairment by inhibiting the GSK-3β activation [71].