BAK1 and nasopharyngeal carcinoma: In addition, Liu et al. (2020) also showed that asiatic acid extracted from Centella asiatica could induce apoptosis via phosphorylation of p38 MAPK and activation of two pro-apoptotic proteins, BAX and BCL-2 homologous antagonist/killer (BAK), in cisplatin-resistant human NPC-039 and NPC-BM cells [118].