MAPK8 and nasopharyngeal carcinoma: Treatment with celastrol, a traditional Chinese medicinal plant, was also found to significantly increase the phosphorylation of p38 MAPK and JNK1/2 in cisplatin-resistant human NPC-039 and NPC-BM NPC cells, triggering cytotoxicity by activation of caspase-mediated apoptotic pathways in these cells [119].