VEGFA and neoplasm: It is demonstrated to be regulated by the balance of pro-angiogenic [e.g., VEGF, fibroblast growth factor (FGF-2)], platelet-derived growth factor subunit B (PDGFB), and soluble vascular cell adhesion molecule (VCAM)] and anti-angiogenic (e.g., angiostatin and endostatin) factors present in the tumor microenvironment [110].