Although serious heart weight side effects were found when high doses of T2 administration [97], a lot of experiment in vivo and in vitro suggested that the T2 could increase the basal metabolic rate and block fat accumulation without side effects of thyroid hormones [98], which indicated T2 was worthy of further research for prevention and cure of diseases, such as obesity and NAFLD [99]. This evidence concerns the gene TG and metabolic dysfunction-associated steatotic liver disease.