Thyroid hormone represented by T3, as an important molecule regulating lipid and glucose metabolism in the body [49,50], has been shown to play an obvious role in the prevention and treatment of NAFLD [62,79], but it is not used clinically due to its non-selective role, that may bring about serious side effects, such as increased heart rate and cardiac hypertrophy. The gene discussed is TG; the disease is metabolic dysfunction-associated steatotic liver disease.